综上所述,本实验结果显示Ki-67和KAI1的异常表达可能在甲状腺癌的进程中起到一定作用。因此,可推测它们在肿瘤良恶性、生物学行为的判定以及预后的评估都有十分重要的指导作用。检测Ki-67和KAI1可以为内蒙古地区甲状腺癌的诊治及预后提供理论依据。但肿瘤的发生、病情进展、浸润周围组织和远处转移是十分复杂的过程,其中涉及多基因、多蛋白、多因素的调控。甲状腺癌中Ki-67和KAI1的具体作用机制还不清楚,需要进行进一步研究。
[1] Choi YJ, Park YL, Koh JH. Prevalence of thyroid cancer at a medical screening center: pathological features of screen-detected thyroid carcinomas. Yonsei Med J 2008;49(5):748-56.
[2] 罗胜兰,俞敏,龚巍巍.甲状腺癌的流行现况及其危险因素[J].中国预防医学杂志,2013,14(04):317-322.
[3] 郭民英,邢永川,陈卫伶,等.Bcl-2、p53和ki-67在甲状腺癌中的表达及其临床意义的研究[J].现代肿瘤医学,2014,22(06):1294-1297.
[4] Lacoste-Collin L,d'Aure D,Berard E,et al. Improvement of the cytological diagnostic accuracy of follicular thyroid lesions by the use of the Ki-67 proliferative index in addition to cytokeratin-19 and HBME-1 immunomarkers: a study of 61 cases of liquid-based FNA cytology with histological controls. Cytopathology: official journal of the British Society for Clinical Cytology,2014,25: 160-169.
[5] Gerdes J,Schwab U,Lemke of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation[J].International journal of cancer,1983,31(1):13-20.
[6] Kakudo K,Wakasa T, Ohta Y, et al. Prognostic classification of thyroid follicular cell tumors using Ki-67 labeling index: Riskstratification of thyroid follicular cell carcinomas Review. Endocr J,2015,30: 1-12.
[7] Mussig K,Wehrmann T, Dittmann H, et al. Expression of the proliferation marker Ki-67 associates with tumour staging and clinical outcome in differentiated thyroid carcinomas. Clinical endocrinology,2012,77: 139-143.
[8] Huang X,Sun Q,Fu H,et al. Both c-Myc and Ki- 67 expression are predictive markers in patients with extranodal NK /T-cell lymphoma,nasal type: a retrospective study in China[J].Pathol Res Pract,2014,210(6):351-356.
文章来源:《内蒙古中医药》 网址: http://www.nmgzyybjb.cn/qikandaodu/2021/0414/784.html
上一篇:民族地区医务社会工作的实践与发展从阶段定位
下一篇:黄河岸边是我家
内蒙古中医药投稿 | 内蒙古中医药编辑部| 内蒙古中医药版面费 | 内蒙古中医药论文发表 | 内蒙古中医药最新目录
Copyright © 2018 《内蒙古中医药》杂志社 版权所有
投稿电话: 投稿邮箱: